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EVA: explain secondary structure prediction scores



subset   subset of proteins common to all prediction methods applied
nprot   number of proteins in subset of proteins common to all prediction methods applied
sots more info standard-of-truth used to evaluate (i.e. method assigning secondary structure given the three-dimensional structure)
rank   Rank of given method. Methods that are not distinguishable since they differ by less than the estimated error given the number of proteins in the common set (ERRsig) are assigned the same rank!
method more info Name of prediction method (all methods)
Q3 definition three-state per-residue accuracy (percentage of correctly predicted residues)
ERRsigQ3   significant deviation for three-state per-residue accuracy (percentage of correctly predicted residues) defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
Q3H%o definition correctly predicted helix residues (percentage of helix observed)
ERRsigQ3H%o   significant deviation for Q3H%o;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
Q3H%p definition correctly predicted helix residues (percentage of helix predicted)
ERRsigQ3H%p   significant deviation for Q3H%p;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
Q3E%o definition correctly predicted strand residues (percentage of helix observed)
ERRsigQ3E%o   significant deviation for Q3E%o;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
Q3E%p definition correctly predicted strand residues (percentage of helix predicted)
ERRsigQ3E%p   significant deviation for Q3E%p;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
Q3L%o definition correctly predicted loop residues (percentage of helix observed)
ERRsigQ3L%o   significant deviation for Q3L%o;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
Q3L%p definition correctly predicted loop residues (percentage of helix predicted)
ERRsigQ3L%p   significant deviation for Q3L%p;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
SOV3 definition per segment accuracy (three states)
ERRsigSOV   significant deviation for SOV;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
sovH definition per segment accuracy for helix residues
ERRsigsovH   significant deviation for sovH;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
sovE definition per segment accuracy for strand residues
ERRsigsovE   significant deviation for sovE;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
sovL definition per segment accuracy for non-regular residues
ERRsigsovL   significant deviation for sovL;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
BAD definition percentage of confused HELIX/STRAND residues (helix predicted as strand, strand predicted as helix)
ERRsigBAD   significant deviation for BAD;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
info definition information index accuracy, with the following convention:
 info  = (infoO + infoP) / 2 
 infoO = info as percentage of observed
 infoP = info as percentage of predicted
ERRsiginfo   significant deviation for info;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
infoO definition information index accuracy (percentage of observed)
ERRsiginfoO   significant deviation for infoO;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
infoP definition information index accuracy (percentage of predicted)
ERRsiginfoP   significant deviation for infoP;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
corrH definition Matthews correlation index for helix
ERRsigcorrH   significant deviation for corrH;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
corrE definition Matthews correlation index for strand
ERRsigcorrE   significant deviation for corrE;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
corrL definition Matthews correlation index for loop
ERRsigcorrL   significant deviation for corrL;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
class definition correctness of predicting secondary structure class according to DSSP (
 class  = (classO + classP) / 2 
 classO = info as percentage of observed
 classP = info as percentage of predicted
ERRsigclass   significant deviation for class;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
classO definition secondary structure class according to DSSP (
ERRsigclassO   significant deviation for classO;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
classP definition secondary structure class predicted (
ERRsigclassP   significant deviation for classP;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
contDH definition difference of :
observed content of helix -
predicted content of helix
ERRsigcontDH   significant deviation for contDH;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x
contDE definition difference of :
observed content of strand -
predicted content of strand
ERRsigcontDE   significant deviation for contDE;   defined by:
ERRsig(x) = SIG(x) / square root (numprot)     SIG(x) = standard deviation for variable x





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