Explanations for terms (EVA)

This page tries to explain some of the jargon used on the EVA WWW pages (http://cubic.bioc.columbia.edu/eva).

Please feel free to send questions and comments to the CUBIC administrator: cubic@cubic.bioc.columbia.edu



Prediction types used by EVA

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'Sequence unique'

Proteins are grouped into two classes:
  1. those that have significant sequence similarity to proteins of known structure (at the date of the submission of the new protein)
  2. those that are novel in that they do NOT have significant sequence similarity to proteins of known structure (at the date of the submission of the new protein)

'Significant similarity' (in sequence)

The term significant sequence similarity refers to the following operational definition:
Two proteins A and B are considered to be significantly similar if we can safely predict that B has the same structure as B by simply comparing their sequences. The current thresholds chosen by EVA are as defined in the respective publication (Rost, 1999, Protein Engineering, 12, 85-94, formula used by EVA).