Free Practicals on Sequence Analysis
Apply what you have learned so far to extract as much information as you can for your favorite protein (or select one of the six interesting cases from the following paper):Six differents protein families at: Iyer LM, Aravind L, Bork P, Hofmann K, Mushegian AR, Zhulin IB, Koonin EV. Quoderat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences. Genome Biol. 2001;2(12):RESEARCH0051. Very didactic! PDF WEB
Other papers on sequence analysis
Cabrera JR, Sanchez-Pulido L, Rojas AM, Valencia A, Manes S, Naranjo JR, Mellstrom B. Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling. J Biol Chem. 2006 May 19;281(20):14330-9. PDF Sanchez-Pulido L, Rojas AM, Van Wely K, Martinez-A C, Valencia A. SPOC: A widely distributed domain associated with cancer, apoptosis and transcription. BMC Bioinformatics. 2004 Jul 7;5(1):91. Web PDF Rojas AM, Sanchez-Pulido L, Futterer A, van Wely KH, Martinez-A C, Valencia A. Death inducer obliterator protein 1 in the context of DNA regulation. Sequence analyses of distant homologues point to a novel functional role. FEBS J. 2005 Jul;272(14):3505-11. PDF