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Proteomics tools

Swiss-Prot

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PeptideCutter

PeptideCutter [references / documentation] predicts potential cleavage sites cleaved by proteases or chemicals in a given protein sequence. This sequence either comes from the SWISS-PROT and/or TrEMBL databases or be entered by the user. PeptideCutter returns the query sequence with the possible cleavage sites mapped on it and /or a table of cleavage site positions.

Enter a SWISS-PROT protein identifier, ID (e.g. ALBU_HUMAN), or accession number, AC (e.g. P04406), or an amino acid sequence (e.g. 'SERVELAT'):

the cleavage of the protein. the fields.

Please, select
all available enzymes and chemicals
only the following selection of enzymes and chemicals

Chymotrypsin-high specificity (C-term to [FYW], not before P)

Chymotrypsin-low specificity (C-term to [FYWML], not before P)

Clostripain (Clostridiopeptidase B)

Glutamyl endopeptidase

NTCB (2-nitro-5-thiocyanobenzoic acid)

Pepsin (pH1.3)

Pepsin (pH>2)

Proline-endopeptidase

Proteinase K

Staphylococcal peptidase I

Thermolysin

Thrombin

Trypsin

for the following enzymes an additional, more sophisticated model can be applied that attributes a probability of cleavage to each site :

Please enter the lowest cleavage probability that you would like to be displayed: %

Please indicate the way you would like the cleavage sites to be displayed

Map of cleavage sites. Please select the number of amino acid within one block:
Table of sites, sorted alphabetically by enzyme and chemical name
Table of sites, sorted sequentially by amino acid number

Please indicate which enzymes to include in the display

All enzymes and chemicals
Enzymes and chemicals cleaving exactly times
Enzymes and chemicals cleaving at least times, and at most times

Last modified 17/Mar/2003 by ELG