Neurotransmitters and other chemical signalling agents
| ADENOSINE (P1 purinoceptors) | |||
|---|---|---|---|
| Precursors: | Mainly AMP (from released ATP) | ||
| Synthesising enzymes: | Mainly 5'-nucleotidase | ||
| Metabolising enzymes: | Adenosine deaminase | ||
| Metabolite: | Inosine | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| A1 | CPA, R-PIA, GR 79236 |
8PT, DPCPX | (-ve)cAMP |
| A2A | CGS21680, CV-1808 |
8PT, CGS 15943 | (+ve)cAMP |
| A2B | Metrifudil | 8PT | (+ve)cAMP |
| A3 MB | R-PIA, NECA | none | (-ve)cAMP |
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Kennedy, C. (1990) Arch. Int. Pharmacodyn. Ther. 303, 30-50.
Zhou, Q-Y. et al. (1992) Proc. Natl. Acad. Sci. USA 89, 7432-7436.
Gamma-Aminobutyric acid
Acetylcholine
Table of Contents
 |
 |
 |
 |
 |
 |
 |
 |