Program: WU-blastp
Database: pdb
Title: Sequence
SeqLen: 352
Matrix: blosum62
BLASTP 2.0MP-WashU [12-Dec-2000] [irix6.5-r10k-L64 21:25:44 12-Dec-2000]
Copyright (C) 1996-2000 Washington University, Saint Louis, Missouri USA.
All Rights Reserved.
Reference: Gish, W. (1996-2000) http://blast.wustl.edu
Query= EMBOSS_001
(352 letters)
Database: pdb
18,733 sequences; 4,016,585 total letters.
Searching....10....20....30....40....50....60....70....80....90....100% done
Smallest
Sum
High Probability
Sequences producing High-scoring Segment Pairs: Score P(N) N
PDB|1SDG|1SDG Sorbitol dehydrogenase (theoretical model) 1061 1.4e-108 1
PDB|1BXZ|1BXZ-A nadp-dependent alcohol dehydrogenasefragm... 272 5.6e-25 1
PDB|1YKF|1YKF-A nadp-dependent alcohol dehydrogenasebiolo... 272 5.6e-25 1
PDB|1KEV|1KEV-A nadp-dependent alcohol dehydrogenase 235 1.5e-19 1
PDB|1PED|1PED-A nadp-dependent alcohol dehydrogenase 235 1.5e-19 1
PDB|1E3E|1E3E-B alcohol dehydrogenase, class ii 145 2.6e-17 2
PDB|1E3I|1E3I-B alcohol dehydrogenase, class ii 145 2.6e-17 2
PDB|1E3L|1E3L-B alcohol dehydrogenase, class iiMutant 145 2.6e-17 2
PDB|1E3E|1E3E-A alcohol dehydrogenase, class ii 145 2.7e-17 2
PDB|1E3I|1E3I-A alcohol dehydrogenase, class ii 145 2.7e-17 2
PDB|1E3L|1E3L-A alcohol dehydrogenase, class iiMutant 145 2.7e-17 2
PDB|1AGN|1AGN-A human sigma alcohol dehydrogenase(sigma adh) 163 2.9e-17 2
PDB|1D1S|1D1S-A alcohol dehydrogenase class iv sigma chai... 163 2.9e-17 2
PDB|1D1T|1D1T-A alcohol dehydrogenase class iv sigma chai... 163 2.9e-17 2
PDB|1CDO|1CDO-A alcohol dehydrogenase 140 2.9e-15 2
PDB|1HSO|1HSO-A class i alcohol dehydrogenase 1, alpha su... 170 5.4e-15 2
PDB|1HDZ|1HDZ-A Alcohol dehydrogenase (beta-1 isoenzyme, ... 161 2.5e-14 2
PDB|1TEH|1TEH-A human chichi alcohol dehydrogenase(glutat... 139 3.2e-14 2
PDB|1EE2|1EE2-A alcohol dehydrogenase 162 3.9e-14 2
PDB|1DDA|1DDA-A alcohol dehydrogenase 159 9.0e-14 2
PDB|1HT0|1HT0-A class i alcohol dehydrogenase 3, gamma su... 159 9.0e-14 2
PDB|1DEH|1DEH-A human beta1 alcohol dehydrogenase(beta1 adh) 153 2.3e-13 2
PDB|1HDX|1HDX-A Alcohol dehydrogenase (beta-1 isoenzyme, ... 153 2.3e-13 2
PDB|1HDY|1HDY-A Alcohol dehydrogenase (beta-2 isoenzyme, ... 153 2.3e-13 2
PDB|1HSZ|1HSZ-A class i alcohol dehydrogenase 1, beta sub... 153 2.3e-13 2
PDB|1HTB|1HTB-A beta3 alcohol dehydrogenase(beta3 adh) 153 2.3e-13 2
PDB|3HUD|3HUD-A Alcohol dehydrogenase (beta-1 isoenzyme) 153 2.3e-13 2
PDB|1AXE|1AXE-A alcohol dehydrogenaseMutantbiological_uni... 155 5.4e-13 2
PDB|1ADB|1ADB-A Alcohol dehydrogenase (adh) complexed wit... 154 7.3e-13 2
PDB|1ADC|1ADC-A Alcohol dehydrogenase (adh) complexed wit... 154 7.3e-13 2
PDB|1ADF|1ADF Alcohol dehydrogenase complexed with inhibi... 154 7.3e-13 2
PDB|1ADG|1ADG Alcohol dehydrogenase complexed with inhibi... 154 7.3e-13 2
PDB|1BTO|1BTO-A liver alcohol dehydrogenase(adh)biologica... 154 7.3e-13 2
PDB|1HLD|1HLD-A Alcohol dehydrogenase (ee isozyme) comple... 154 7.3e-13 2
PDB|1LDE|1LDE-A liver alcohol dehydrogenase(adh)biologica... 154 7.3e-13 2
PDB|1LDY|1LDY-A alcohol dehydrogenase(adh)biological_unit... 154 7.3e-13 2
PDB|2OHX|2OHX-A Alcohol dehydrogenase (holo form) complex... 154 7.3e-13 2
PDB|2OXI|2OXI-A Alcohol dehydrogenase (holo, liver) compl... 154 7.3e-13 2
PDB|3BTO|3BTO-A liver alcohol dehydrogenase(adh)biologica... 154 7.3e-13 2
PDB|5ADH|5ADH Apo-liver alcohol dehydrogenase complex wit... 154 7.3e-13 2
PDB|6ADH|6ADH-A Holo-liver alcohol dehydrogenase complex ... 154 7.3e-13 2
PDB|8ADH|8ADH Apo-liver alcohol dehydrogenase 154 7.3e-13 2
PDB|1A71|1A71-A liver alcohol dehydrogenaseMutantbiologic... 155 1.4e-12 2
PDB|1A72|1A72 horse liver alcohol dehydrogenaseMutantbiol... 155 1.4e-12 2
PDB|1AXG|1AXG-A alcohol dehydrogenaseMutantbiological_uni... 154 1.9e-12 2
PDB|1QLH|1QLH-A alcohol dehydrogenase(adh, alcohol dehydr... 154 3.0e-12 2
PDB|1QLJ|1QLJ-A alcohol dehydrogenase(adh)Mutant 154 3.0e-12 2
PDB|7ADH|7ADH Isonicotinimidylated liver alcohol dehydrog... 141 2.6e-10 2
PDB|1QOR|1QOR-A Quinone oxidoreductase complexed with nadph 95 2.2e-06 2
PDB|1D3B|1D3B-C small nuclear ribonucleoprotein sm d3frag... 51 0.71 1
PDB|1EEP|1EEP-A inosine 5'-monophosphate dehydrogenase 72 0.76 1
PDB|1EEP|1EEP-B inosine 5'-monophosphate dehydrogenase 72 0.76 1
PDB|2ECH|2ECH Echistatin (NMR, 8 structures) 50 0.80 1
PDB|1AHO|1AHO toxin ii 49 0.87 1
PDB|1PTX|1PTX Scorpion toxin ii 49 0.87 1
PDB|1QO8|1QO8-A flavocytochrome c3 fumarate reductase 73 0.91 1
PDB|1D3B|1D3B-A small nuclear ribonucleoprotein sm d3frag... 51 0.92 1
PDB|1EBG|1EBG-A Enolase (2-phospho-d-glycerate hydrolase)... 71 0.95 1
PDB|1EBH|1EBH-A Enolase (2-phospho-d-glycerate hydrolase)... 71 0.95 1
PDB|1ELS|1ELS Enolase (2-phospho-d-glycerate hydrolase) c... 71 0.95 1
PDB|1NEL|1NEL Enolase (2-phospho-d-glycerate hydrolase) c... 71 0.95 1
PDB|1ONE|1ONE-A enolase(2-phospho-d-glycerate hydrolase) 71 0.95 1
PDB|2ONE|2ONE-A enolase(2-phospho-d-glycerate hydrolase)b... 71 0.95 1
PDB|3ENL|3ENL Enolase (2-phospho-D-glycerate hydrolase) (... 71 0.95 1
PDB|4ENL|4ENL Enolase (2-phospho-D-glycerate hydrolase) (... 71 0.95 1
PDB|5ENL|5ENL Enolase (2-phospho-D-glycerate hydrolase) c... 71 0.95 1
PDB|6ENL|6ENL Enolase (2-phospho-D-glycerate hydrolase) c... 71 0.95 1
PDB|7ENL|7ENL Enolase (2-phospho-D-glycerate hydrolase) c... 71 0.95 1
PDB|1NRA|1NRA Neurotoxin v, cse-v (NMR, minimized average... 47 0.97 1
PDB|1NRB|1NRB Neurotoxin v, cse-v (NMR, 20 structures) 47 0.97 1
PDB|1D3B|1D3B-G small nuclear ribonucleoprotein sm d3frag... 51 0.98 1
PDB|1D4D|1D4D-A flavocytochrome c fumarate reductase 71 0.98 1
PDB|1D4E|1D4E-A flavocytochrome c fumarate reductase 71 0.98 1
PDB|1D4C|1D4C-B flavocytochrome c fumarate reductase 71 0.98 1
PDB|1D4C|1D4C-C flavocytochrome c fumarate reductase 71 0.98 1
PDB|1D4C|1D4C-A flavocytochrome c fumarate reductase 71 0.98 1
PDB|1LAY|1LAY cytomegalovirus protease(assemblin)Mutant 65 0.99 1
PDB|1D3B|1D3B-E small nuclear ribonucleoprotein sm d3frag... 51 0.993 1
PDB|1SKY|1SKY-B f1-atpase(f1-atp synthase) 57 0.994 2
PDB|1NEA|1NEA Toxin alpha (NMR, 8 structures) 45 0.996 1
PDB|1SFC|1SFC-D synaptobrevin 2fragment: proteolytically ... 50 0.99993 1
>PDB|1SDG|1SDG Sorbitol dehydrogenase (theoretical model)
Length = 347
Score = 1061 (378.5 bits), Expect = 1.4e-108, P = 1.4e-108
Identities = 210/349 (60%), Positives = 260/349 (74%)
Query: 2 ASDNLSAVLYKQNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDP 61
A++NLS V++ DLRLE PIPEP +EVLL+M VGICGSDVHY++ GRI DF+VK P
Sbjct: 4 AAENLSLVVHGPGDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQ-GRIGDFVVKKP 62
Query: 62 MVIGHEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPD 121
MV+GHEASGTVVKVG V+HL+ GDRVA++PG P + +FCK G+YNL P + FCATPPD
Sbjct: 63 MVLGHEASGTVVKVGSLVRHLQPGDRVAIQPGAPRQTDEFCKIGRYNLSPTIFFCATPPD 122
Query: 122 DGNLARYYVHAADFCHKLPDNVSLEEGALLEPLSVGVHACRRAGVQLGTTVLVIGAGPIG 181
DGNL R+Y H A+FC+KLPDNV+ EEGAL+EPLSVG+HACRRAGV LG VLV GAGPIG
Sbjct: 123 DGNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIG 182
Query: 182 LVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDL 240
LV++LAAKA GA VV T S RL AK GAD L + EE I +++ +G
Sbjct: 183 LVNLLAAKAMGAAQVVVTDLSASRLSKAKEVGADFILEISNESPEE--IAKKVEGLLGSK 240
Query: 241 PNVTIDCSGNEKCITIGINITRTGGTLMLVGMGSQMVTVPLVNACAREIDIKSVFRYCND 300
P VTI+C+G E I GI T +GGTL+LVG+GS+M +VPLV+A RE+DIK VFRYCN
Sbjct: 241 PEVTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNT 300
Query: 301 YPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARKKADNTIKVMISC 349
+P+A+ M+AS NVK LVTH F LE+ ++AFE ++K +KVMI C
Sbjct: 301 WPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLG--LKVMIKC 347
>PDB|1BXZ|1BXZ-A nadp-dependent alcohol dehydrogenasefragment:
nucleotide-binding domain, catalytic domain; biological_unit:
homotetramer
Length = 352
Score = 272 (100.8 bits), Expect = 5.6e-25, P = 5.6e-25
Identities = 99/347 (28%), Positives = 161/347 (46%)
Query: 19 EQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKVGKN 78
+++P P P D ++ +A V C SD+H G I + + M++GHEA G VV+VG
Sbjct: 17 KEKPAPGPF-DAIVRPLA-VAPCTSDIHTVFEGAIGE---RHNMILGHEAVGEVVEVGSE 71
Query: 79 VKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLT--FCATPPDDGNLARYY-VHAADF 135
VK K GDRV V P R + G + + + + DG ++ V+ AD
Sbjct: 72 VKDFKPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADM 131
Query: 136 --CHKLPDNVSLEEGALL-EPLSVGVHACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYG 192
H LP + LE ++ + ++ G H A ++LG TV V+G GP+GL++V AK G
Sbjct: 132 NLAH-LPKEIPLEAAVMIPDMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRG 190
Query: 193 AF-VVCTARSPRRLEVAKNCGA-DVTLVVD-PAKEEESSIIERIRSAIGDLPNVTIDCSG 249
A ++ P ++ AK GA D+ D P + + ++ E G + I G
Sbjct: 191 AGRIIAVGSRPVCVDAAKYYGATDIVNYKDGPIESQIMNLTE------GKGVDAAIIAGG 244
Query: 250 NEKCITIGINITRTGGTLMLVG-MGS-QMVTVPLVN-ACAR-EIDIKSVFRYCNDYPIAL 305
N + + I + GGT+ V G +++ VP + C IK C + +
Sbjct: 245 NADIMATAVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGL--CPGGRLRM 302
Query: 306 E----MVASGRCNVKQLVTHSFKLEQTVD-AFEAARKKADNTIKVMI 347
E +V R + +LVTH F+ ++ AF + K + IK ++
Sbjct: 303 ERLIDLVFYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVV 349
>PDB|1YKF|1YKF-A nadp-dependent alcohol dehydrogenasebiological_unit:
homotetramer;
Length = 352
Score = 272 (100.8 bits), Expect = 5.6e-25, P = 5.6e-25
Identities = 99/347 (28%), Positives = 161/347 (46%)
Query: 19 EQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKVGKN 78
+++P P P D ++ +A V C SD+H G I + + M++GHEA G VV+VG
Sbjct: 17 KEKPAPGPF-DAIVRPLA-VAPCTSDIHTVFEGAIGE---RHNMILGHEAVGEVVEVGSE 71
Query: 79 VKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLT--FCATPPDDGNLARYY-VHAADF 135
VK K GDRV V P R + G + + + + DG ++ V+ AD
Sbjct: 72 VKDFKPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADM 131
Query: 136 --CHKLPDNVSLEEGALL-EPLSVGVHACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYG 192
H LP + LE ++ + ++ G H A ++LG TV V+G GP+GL++V AK G
Sbjct: 132 NLAH-LPKEIPLEAAVMIPDMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRG 190
Query: 193 AF-VVCTARSPRRLEVAKNCGA-DVTLVVD-PAKEEESSIIERIRSAIGDLPNVTIDCSG 249
A ++ P ++ AK GA D+ D P + + ++ E G + I G
Sbjct: 191 AGRIIAVGSRPVCVDAAKYYGATDIVNYKDGPIESQIMNLTE------GKGVDAAIIAGG 244
Query: 250 NEKCITIGINITRTGGTLMLVG-MGS-QMVTVPLVN-ACAR-EIDIKSVFRYCNDYPIAL 305
N + + I + GGT+ V G +++ VP + C IK C + +
Sbjct: 245 NADIMATAVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGL--CPGGRLRM 302
Query: 306 E----MVASGRCNVKQLVTHSFKLEQTVD-AFEAARKKADNTIKVMI 347
E +V R + +LVTH F+ ++ AF + K + IK ++
Sbjct: 303 ERLIDLVFYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVV 349
>PDB|1KEV|1KEV-A nadp-dependent alcohol dehydrogenase
Length = 351
Score = 235 (87.8 bits), Expect = 1.5e-19, P = 1.5e-19
Identities = 91/346 (26%), Positives = 156/346 (45%)
Query: 19 EQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKVGKN 78
++RP+ D ++ +A V C SD+H G + D + M++GHEA G VV+VG
Sbjct: 17 KERPVAG-SYDAIVRPLA-VSPCTSDIHTVFEGALGD---RKNMILGHEAVGEVVEVGSE 71
Query: 79 VKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLT--FCATPPDDGNLARYY-VHAADF 135
VK K GDRV V P R + G + + + DG Y+ V+ AD
Sbjct: 72 VKDFKPGDRVIVPCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADM 131
Query: 136 -CHKLPDNVSLEEGALL-EPLSVGVHACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGA 193
LP ++ LE ++ + ++ G H A +Q+G++V+VIG G +GL+ + AK GA
Sbjct: 132 NLAILPKDMPLENAVMITDMMTTGFHGAELADIQMGSSVVVIGIGAVGLMGIAGAKLRGA 191
Query: 194 F-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAI-GDLPNVTIDCSGNE 251
++ P +E AK GA D + I++++ G + I G
Sbjct: 192 GRIIGVGSRPICVEAAKFYGA-----TDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGS 246
Query: 252 KCITIGINITRTGGTLMLV---GMGSQMVTVPLVN-ACAR-EIDIKSVFRYCNDYPIALE 306
+ ++ +++ + GG + + G G ++ +P V C IK C + E
Sbjct: 247 ETLSQAVSMVKPGGIISNINYHGSGDALL-IPRVEWGCGMAHKTIKGGL--CPGGRLRAE 303
Query: 307 M----VASGRCNVKQLVTHSFK-LEQTVDAFEAARKKADNTIKVMI 347
M V R ++ +LVTH + + +A + K + IK ++
Sbjct: 304 MLRDMVVYNRVDLSKLVTHVYHGFDHIEEALLLMKDKPKDLIKAVV 349
>PDB|1PED|1PED-A nadp-dependent alcohol dehydrogenase
Length = 351
Score = 235 (87.8 bits), Expect = 1.5e-19, P = 1.5e-19
Identities = 91/346 (26%), Positives = 156/346 (45%)
Query: 19 EQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKVGKN 78
++RP+ D ++ +A V C SD+H G + D + M++GHEA G VV+VG
Sbjct: 17 KERPVAG-SYDAIVRPLA-VSPCTSDIHTVFEGALGD---RKNMILGHEAVGEVVEVGSE 71
Query: 79 VKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLT--FCATPPDDGNLARYY-VHAADF 135
VK K GDRV V P R + G + + + DG Y+ V+ AD
Sbjct: 72 VKDFKPGDRVIVPCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADM 131
Query: 136 -CHKLPDNVSLEEGALL-EPLSVGVHACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGA 193
LP ++ LE ++ + ++ G H A +Q+G++V+VIG G +GL+ + AK GA
Sbjct: 132 NLAILPKDMPLENAVMITDMMTTGFHGAELADIQMGSSVVVIGIGAVGLMGIAGAKLRGA 191
Query: 194 F-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAI-GDLPNVTIDCSGNE 251
++ P +E AK GA D + I++++ G + I G
Sbjct: 192 GRIIGVGSRPICVEAAKFYGA-----TDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGS 246
Query: 252 KCITIGINITRTGGTLMLV---GMGSQMVTVPLVN-ACAR-EIDIKSVFRYCNDYPIALE 306
+ ++ +++ + GG + + G G ++ +P V C IK C + E
Sbjct: 247 ETLSQAVSMVKPGGIISNINYHGSGDALL-IPRVEWGCGMAHKTIKGGL--CPGGRLRAE 303
Query: 307 M----VASGRCNVKQLVTHSFK-LEQTVDAFEAARKKADNTIKVMI 347
M V R ++ +LVTH + + +A + K + IK ++
Sbjct: 304 MLRDMVVYNRVDLSKLVTHVYHGFDHIEEALLLMKDKPKDLIKAVV 349
>PDB|1E3E|1E3E-B alcohol dehydrogenase, class ii
Length = 373
Score = 145 (56.1 bits), Expect = 2.6e-17, Sum P(2) = 2.6e-17
Identities = 38/120 (31%), Positives = 59/120 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+A+ +K L +E+ + PK EV +Q+ +C +D++ + + A F P+V+G
Sbjct: 8 AAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALF----PVVLG 63
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNL 125
HE +G V VG V + K GD+V C+RC+ C NLC L P D L
Sbjct: 64 HECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQEL 123
Score = 123 (48.4 bits), Expect = 2.6e-17, Sum P(2) = 2.6e-17
Identities = 53/228 (23%), Positives = 103/228 (45%)
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIG 181
+ ++Y V + ++ D +LE L+ S G A A V G+T V G G +G
Sbjct: 146 SFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPGSTCAVFGLGCVG 205
Query: 182 LVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDL 240
L +++ K GA ++ + + AK GA T ++P +E + + + I
Sbjct: 206 LSAIIGCKIAGASRIIAIDINGEKFPKAKALGA--TDCLNP-RELDKPVQDVITELTAGG 262
Query: 241 PNVTIDCSGNEKCITIGINITRTG-GTLMLVGMGSQMVTVPLVNAC-AREID--IKSVFR 296
+ ++DC+G + + ++ T G G+ +VG +T+P V+ R I+ ++
Sbjct: 263 VDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGRSINGTFFGGWK 322
Query: 297 YCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK-KADNTI 343
+ P + + + ++ LVTH+ E DA + ++ K+ TI
Sbjct: 323 SVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTI 370
>PDB|1E3I|1E3I-B alcohol dehydrogenase, class ii
Length = 373
Score = 145 (56.1 bits), Expect = 2.6e-17, Sum P(2) = 2.6e-17
Identities = 38/120 (31%), Positives = 59/120 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+A+ +K L +E+ + PK EV +Q+ +C +D++ + + A F P+V+G
Sbjct: 8 AAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALF----PVVLG 63
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNL 125
HE +G V VG V + K GD+V C+RC+ C NLC L P D L
Sbjct: 64 HECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQEL 123
Score = 123 (48.4 bits), Expect = 2.6e-17, Sum P(2) = 2.6e-17
Identities = 53/228 (23%), Positives = 103/228 (45%)
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIG 181
+ ++Y V + ++ D +LE L+ S G A A V G+T V G G +G
Sbjct: 146 SFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPGSTCAVFGLGCVG 205
Query: 182 LVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDL 240
L +++ K GA ++ + + AK GA T ++P +E + + + I
Sbjct: 206 LSAIIGCKIAGASRIIAIDINGEKFPKAKALGA--TDCLNP-RELDKPVQDVITELTAGG 262
Query: 241 PNVTIDCSGNEKCITIGINITRTG-GTLMLVGMGSQMVTVPLVNAC-AREID--IKSVFR 296
+ ++DC+G + + ++ T G G+ +VG +T+P V+ R I+ ++
Sbjct: 263 VDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGRSINGTFFGGWK 322
Query: 297 YCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK-KADNTI 343
+ P + + + ++ LVTH+ E DA + ++ K+ TI
Sbjct: 323 SVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTI 370
>PDB|1E3L|1E3L-B alcohol dehydrogenase, class iiMutant
Length = 373
Score = 145 (56.1 bits), Expect = 2.6e-17, Sum P(2) = 2.6e-17
Identities = 38/120 (31%), Positives = 59/120 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+A+ +K L +E+ + PK EV +Q+ +C +D++ + + A F P+V+G
Sbjct: 8 AAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCHTDINATDPKKKALF----PVVLG 63
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNL 125
HE +G V VG V + K GD+V C+RC+ C NLC L P D L
Sbjct: 64 HECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQEL 123
Score = 123 (48.4 bits), Expect = 2.6e-17, Sum P(2) = 2.6e-17
Identities = 53/228 (23%), Positives = 103/228 (45%)
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIG 181
+ ++Y V + ++ D +LE L+ S G A A V G+T V G G +G
Sbjct: 146 SFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPGSTCAVFGLGCVG 205
Query: 182 LVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDL 240
L +++ K GA ++ + + AK GA T ++P +E + + + I
Sbjct: 206 LSAIIGCKIAGASRIIAIDINGEKFPKAKALGA--TDCLNP-RELDKPVQDVITELTAGG 262
Query: 241 PNVTIDCSGNEKCITIGINITRTG-GTLMLVGMGSQMVTVPLVNAC-AREID--IKSVFR 296
+ ++DC+G + + ++ T G G+ +VG +T+P V+ R I+ ++
Sbjct: 263 VDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGRSINGTFFGGWK 322
Query: 297 YCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK-KADNTI 343
+ P + + + ++ LVTH+ E DA + ++ K+ TI
Sbjct: 323 SVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTI 370
>PDB|1E3E|1E3E-A alcohol dehydrogenase, class ii
Length = 376
Score = 145 (56.1 bits), Expect = 2.7e-17, Sum P(2) = 2.7e-17
Identities = 38/120 (31%), Positives = 59/120 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+A+ +K L +E+ + PK EV +Q+ +C +D++ + + A F P+V+G
Sbjct: 11 AAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALF----PVVLG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNL 125
HE +G V VG V + K GD+V C+RC+ C NLC L P D L
Sbjct: 67 HECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQEL 126
Score = 123 (48.4 bits), Expect = 2.7e-17, Sum P(2) = 2.7e-17
Identities = 53/228 (23%), Positives = 103/228 (45%)
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIG 181
+ ++Y V + ++ D +LE L+ S G A A V G+T V G G +G
Sbjct: 149 SFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPGSTCAVFGLGCVG 208
Query: 182 LVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDL 240
L +++ K GA ++ + + AK GA T ++P +E + + + I
Sbjct: 209 LSAIIGCKIAGASRIIAIDINGEKFPKAKALGA--TDCLNP-RELDKPVQDVITELTAGG 265
Query: 241 PNVTIDCSGNEKCITIGINITRTG-GTLMLVGMGSQMVTVPLVNAC-AREID--IKSVFR 296
+ ++DC+G + + ++ T G G+ +VG +T+P V+ R I+ ++
Sbjct: 266 VDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGRSINGTFFGGWK 325
Query: 297 YCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK-KADNTI 343
+ P + + + ++ LVTH+ E DA + ++ K+ TI
Sbjct: 326 SVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTI 373
>PDB|1E3I|1E3I-A alcohol dehydrogenase, class ii
Length = 376
Score = 145 (56.1 bits), Expect = 2.7e-17, Sum P(2) = 2.7e-17
Identities = 38/120 (31%), Positives = 59/120 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+A+ +K L +E+ + PK EV +Q+ +C +D++ + + A F P+V+G
Sbjct: 11 AAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALF----PVVLG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNL 125
HE +G V VG V + K GD+V C+RC+ C NLC L P D L
Sbjct: 67 HECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQEL 126
Score = 123 (48.4 bits), Expect = 2.7e-17, Sum P(2) = 2.7e-17
Identities = 53/228 (23%), Positives = 103/228 (45%)
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIG 181
+ ++Y V + ++ D +LE L+ S G A A V G+T V G G +G
Sbjct: 149 SFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPGSTCAVFGLGCVG 208
Query: 182 LVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDL 240
L +++ K GA ++ + + AK GA T ++P +E + + + I
Sbjct: 209 LSAIIGCKIAGASRIIAIDINGEKFPKAKALGA--TDCLNP-RELDKPVQDVITELTAGG 265
Query: 241 PNVTIDCSGNEKCITIGINITRTG-GTLMLVGMGSQMVTVPLVNAC-AREID--IKSVFR 296
+ ++DC+G + + ++ T G G+ +VG +T+P V+ R I+ ++
Sbjct: 266 VDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGRSINGTFFGGWK 325
Query: 297 YCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK-KADNTI 343
+ P + + + ++ LVTH+ E DA + ++ K+ TI
Sbjct: 326 SVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTI 373
>PDB|1E3L|1E3L-A alcohol dehydrogenase, class iiMutant
Length = 376
Score = 145 (56.1 bits), Expect = 2.7e-17, Sum P(2) = 2.7e-17
Identities = 38/120 (31%), Positives = 59/120 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+A+ +K L +E+ + PK EV +Q+ +C +D++ + + A F P+V+G
Sbjct: 11 AAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCHTDINATDPKKKALF----PVVLG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNL 125
HE +G V VG V + K GD+V C+RC+ C NLC L P D L
Sbjct: 67 HECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQEL 126
Score = 123 (48.4 bits), Expect = 2.7e-17, Sum P(2) = 2.7e-17
Identities = 53/228 (23%), Positives = 103/228 (45%)
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIG 181
+ ++Y V + ++ D +LE L+ S G A A V G+T V G G +G
Sbjct: 149 SFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPGSTCAVFGLGCVG 208
Query: 182 LVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDL 240
L +++ K GA ++ + + AK GA T ++P +E + + + I
Sbjct: 209 LSAIIGCKIAGASRIIAIDINGEKFPKAKALGA--TDCLNP-RELDKPVQDVITELTAGG 265
Query: 241 PNVTIDCSGNEKCITIGINITRTG-GTLMLVGMGSQMVTVPLVNAC-AREID--IKSVFR 296
+ ++DC+G + + ++ T G G+ +VG +T+P V+ R I+ ++
Sbjct: 266 VDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGRSINGTFFGGWK 325
Query: 297 YCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK-KADNTI 343
+ P + + + ++ LVTH+ E DA + ++ K+ TI
Sbjct: 326 SVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTI 373
>PDB|1AGN|1AGN-A human sigma alcohol dehydrogenase(sigma adh)
Length = 373
Score = 163 (62.4 bits), Expect = 2.9e-17, Sum P(2) = 2.9e-17
Identities = 38/112 (33%), Positives = 63/112 (56%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++Q +E+ + PK EV +++ GIC +D H + ++ F P+++G
Sbjct: 11 AAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKF----PVIVG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCKEGKYNLC--PDLT 114
HEA+G V +G+ V +K GD+V + +P CR C C+ NLC D+T
Sbjct: 67 HEATGIVESIGEGVTTVKPGDKV-IPLFLPQCRECNACRNPDGNLCIRSDIT 117
Score = 102 (41.0 bits), Expect = 2.9e-17, Sum P(2) = 2.9e-17
Identities = 51/206 (24%), Positives = 93/206 (45%)
Query: 138 KLPDNVSLEEGALLE-PLSVGVHACRRAG-VQLGTTVLVIGAGPIGLVSVLAAKAYGAF- 194
K+ D E+ L+ S G A + G V+ G+T +V G G +GL ++ K+ GA
Sbjct: 158 KIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASR 217
Query: 195 VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLPNVTIDCSGN-EKC 253
++ + + E A GA T + P K+ I E + G+ T + G+ E
Sbjct: 218 IIGIDLNKDKFEKAMAVGA--TECISP-KDSTKPISEVLSEMTGNNVGYTFEVIGHLETM 274
Query: 254 ITIGINITRTGGTLMLVGM--GSQMVTV-PLVNACAREID--IKSVFRYCNDYP-IALEM 307
I + GT ++VG+ ++M+T P++ R + + +D P + E
Sbjct: 275 IDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEF 334
Query: 308 VASGRCNVKQLVTHSFKLEQTVDAFE 333
+A + ++ QL+TH ++ + FE
Sbjct: 335 LAK-KFDLDQLITHVLPFKKISEGFE 359
>PDB|1D1S|1D1S-A alcohol dehydrogenase class iv sigma chain(retinol
dehydrogenase, gastric alcohol dehydrogenase)
Length = 373
Score = 163 (62.4 bits), Expect = 2.9e-17, Sum P(2) = 2.9e-17
Identities = 38/112 (33%), Positives = 63/112 (56%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++Q +E+ + PK EV +++ GIC +D H + ++ F P+++G
Sbjct: 11 AAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKF----PVIVG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCKEGKYNLC--PDLT 114
HEA+G V +G+ V +K GD+V + +P CR C C+ NLC D+T
Sbjct: 67 HEATGIVESIGEGVTTVKPGDKV-IPLFLPQCRECNACRNPDGNLCIRSDIT 117
Score = 102 (41.0 bits), Expect = 2.9e-17, Sum P(2) = 2.9e-17
Identities = 51/206 (24%), Positives = 93/206 (45%)
Query: 138 KLPDNVSLEEGALLE-PLSVGVHACRRAG-VQLGTTVLVIGAGPIGLVSVLAAKAYGAF- 194
K+ D E+ L+ S G A + G V+ G+T +V G G +GL ++ K+ GA
Sbjct: 158 KIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASR 217
Query: 195 VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLPNVTIDCSGN-EKC 253
++ + + E A GA T + P K+ I E + G+ T + G+ E
Sbjct: 218 IIGIDLNKDKFEKAMAVGA--TECISP-KDSTKPISEVLSEMTGNNVGYTFEVIGHLETM 274
Query: 254 ITIGINITRTGGTLMLVGM--GSQMVTV-PLVNACAREID--IKSVFRYCNDYP-IALEM 307
I + GT ++VG+ ++M+T P++ R + + +D P + E
Sbjct: 275 IDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEF 334
Query: 308 VASGRCNVKQLVTHSFKLEQTVDAFE 333
+A + ++ QL+TH ++ + FE
Sbjct: 335 LAK-KFDLDQLITHVLPFKKISEGFE 359
>PDB|1D1T|1D1T-A alcohol dehydrogenase class iv sigma chain(retinol
dehydrogenase, gastric alcohol dehydrogenase)Mutant
Length = 373
Score = 163 (62.4 bits), Expect = 2.9e-17, Sum P(2) = 2.9e-17
Identities = 38/112 (33%), Positives = 63/112 (56%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++Q +E+ + PK EV +++ GIC +D H + ++ F P+++G
Sbjct: 11 AAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKF----PVIVG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCKEGKYNLC--PDLT 114
HEA+G V +G+ V +K GD+V + +P CR C C+ NLC D+T
Sbjct: 67 HEATGIVESIGEGVTTVKPGDKV-IPLFLPQCRECNACRNPDGNLCIRSDIT 117
Score = 102 (41.0 bits), Expect = 2.9e-17, Sum P(2) = 2.9e-17
Identities = 51/206 (24%), Positives = 93/206 (45%)
Query: 138 KLPDNVSLEEGALLE-PLSVGVHACRRAG-VQLGTTVLVIGAGPIGLVSVLAAKAYGAF- 194
K+ D E+ L+ S G A + G V+ G+T +V G G +GL ++ K+ GA
Sbjct: 158 KIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASR 217
Query: 195 VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLPNVTIDCSGN-EKC 253
++ + + E A GA T + P K+ I E + G+ T + G+ E
Sbjct: 218 IIGIDLNKDKFEKAMAVGA--TECISP-KDSTKPISEVLSEMTGNNVGYTFEVIGHLETM 274
Query: 254 ITIGINITRTGGTLMLVGM--GSQMVTV-PLVNACAREID--IKSVFRYCNDYP-IALEM 307
I + GT ++VG+ ++M+T P++ R + + +D P + E
Sbjct: 275 IDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEF 334
Query: 308 VASGRCNVKQLVTHSFKLEQTVDAFE 333
+A + ++ QL+TH ++ + FE
Sbjct: 335 LAK-KFDLDQLITHVLPFKKISEGFE 359
>PDB|1CDO|1CDO-A alcohol dehydrogenase
Length = 374
Score = 140 (54.3 bits), Expect = 2.9e-15, Sum P(2) = 2.9e-15
Identities = 31/105 (29%), Positives = 56/105 (53%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AV ++ N L +E+ + P +E+ +++ G+C +D+++ G+ D P+V+G
Sbjct: 11 AAVAWEANKPLVIEEIEVDVPHANEIRIKIIATGVCHTDLYHLFEGKHKDGF---PVVLG 67
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HE +G V VG V + G++V C C+FC+ K N C
Sbjct: 68 HEGAGIVESVGPGVTEFQPGEKVIPLFISQCGECRFCQSPKTNQC 112
Score = 109 (43.4 bits), Expect = 2.9e-15, Sum P(2) = 2.9e-15
Identities = 53/221 (23%), Positives = 95/221 (42%)
Query: 138 KLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF- 194
K+ + L+ LL +S G A A V+ G+T V G G +GL +V+ + GA
Sbjct: 160 KIDPSAPLDTVCLLGCGVSTGFGAAVNTAKVEPGSTCAVFGLGAVGLAAVMGCHSAGAKR 219
Query: 195 VVCTARSPRRLEVAKNCGADVTLVVDPAKEEE--SSIIERIRSAIGDLPNVTIDCSGNEK 252
++ +P + E AK GA T V+P E S ++ ++ + D +++C GN
Sbjct: 220 IIAVDLNPDKFEKAKVFGA--TDFVNPNDHSEPISQVLSKMTNGGVDF---SLECVGNVG 274
Query: 253 CITIGINITRTG-GTLMLVGMGS--QMVTVPLVNACAR--EIDIKSVFRYCNDYPIALEM 307
+ + G G +LVG + T P+ R + + F+ + P ++
Sbjct: 275 VMRNALESCLKGWGVSVLVGWTDLHDVATRPIQLIAGRTWKGSMFGGFKGKDGVPKMVKA 334
Query: 308 VASGRCNVKQLVTHSFKLEQTVDAFEAARKKADNTIKVMIS 348
+ + + +TH LE DA + K I+ ++S
Sbjct: 335 YLDKKVKLDEFITHRMPLESVNDAIDLM--KHGKCIRTVLS 373
>PDB|1HSO|1HSO-A class i alcohol dehydrogenase 1, alpha subunitfragment: alpha
subunit; (alcohol dehydrogenase (class i), alpha polypeptide)aldehyde
reductase; alcohol dehydrogenase 1 (class i), alpha polypeptide;
Length = 374
Score = 170 (64.9 bits), Expect = 5.4e-15, Sum P(2) = 5.4e-15
Identities = 37/106 (34%), Positives = 60/106 (56%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E+ + PK EV ++M VGICG+D H + P+++G
Sbjct: 11 AAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTPL----PVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V + +P C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKV-IPLAIPQCGKCRICKNPESNYC 111
Score = 72 (30.4 bits), Expect = 5.4e-15, Sum P(2) = 5.4e-15
Identities = 41/188 (21%), Positives = 81/188 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +++ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSM 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFEAAR 336
P++ R I F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLH 363
Query: 337 K-KADNTI 343
K+ TI
Sbjct: 364 SGKSIRTI 371
>PDB|1HDZ|1HDZ-A Alcohol dehydrogenase (beta-1 isoenzyme, human) mutant with
arg 47 replaced by gly (r47g) complexed with nad+
Length = 374
Score = 161 (61.7 bits), Expect = 2.5e-14, Sum P(2) = 2.5e-14
Identities = 36/105 (34%), Positives = 57/105 (54%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E + PK EV ++M VGICG+D H + + P+++G
Sbjct: 11 AAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICGTDDHVVS----GNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYC 111
Score = 76 (31.8 bits), Expect = 2.5e-14, Sum P(2) = 2.5e-14
Identities = 38/177 (21%), Positives = 77/177 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +V+ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSI 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P++ R + F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFD 360
>PDB|1TEH|1TEH-A human chichi alcohol dehydrogenase(glutathione-dependent
formaldehyde dehydrogenase, class iii adh)
Length = 373
Score = 139 (54.0 bits), Expect = 3.2e-14, Sum P(2) = 3.2e-14
Identities = 35/96 (36%), Positives = 51/96 (53%)
Query: 16 LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKV 75
L +E+ + PK EV +++ +C +D Y G AD P+++GHE +G V V
Sbjct: 19 LSIEEIEVAPPKAHEVRIKIIATAVCHTDA-YTLSG--ADPEGCFPVILGHEGAGIVESV 75
Query: 76 GKNVKHLKKGDRVAVEPGVP-CRRCQFCKEGKYNLC 110
G+ V LK GD V + +P C C+FC K NLC
Sbjct: 76 GEGVTKLKAGDTV-IPLYIPQCGECKFCLNPKTNLC 110
Score = 100 (40.3 bits), Expect = 3.2e-14, Sum P(2) = 3.2e-14
Identities = 51/216 (23%), Positives = 91/216 (42%)
Query: 129 YVHAADFC-HKLPDNVSLEEGALLE-PLSVGVHAC-RRAGVQLGTTVLVIGAGPIGLVSV 185
Y AD K+ L++ LL +S G A A ++ G+ V G G +GL +
Sbjct: 148 YTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPGSVCAVFGLGGVGLAVI 207
Query: 186 LAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLP-NV 243
+ K GA ++ + + AK GA T ++P ++ S I+ + + D +
Sbjct: 208 MGCKVAGASRIIGVDINKDKFARAKEFGA--TECINP--QDFSKPIQEVLIEMTDGGVDY 263
Query: 244 TIDCSGNEKCITIGINITRTG-GTLMLVGM---GSQMVTVP--LVNACAREIDIKSVFRY 297
+ +C GN K + + G G ++VG+ G ++ T P LV + ++
Sbjct: 264 SFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFGGWKS 323
Query: 298 CNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P + S + V + VTH+ ++ AFE
Sbjct: 324 VESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE 359
>PDB|1EE2|1EE2-A alcohol dehydrogenase
Length = 373
Score = 162 (62.1 bits), Expect = 3.9e-14, Sum P(2) = 3.9e-14
Identities = 45/153 (29%), Positives = 77/153 (50%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++Q +E+ + PK EV ++M GIC SD H +A P++ G
Sbjct: 11 AAVLWEQKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDDHVVSGTLVAPL----PVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCKEGKYNLC-PDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V + +P C +C CK + NLC +L+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKV-IPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTMQDG 125
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 126 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 156
Score = 73 (30.8 bits), Expect = 3.9e-14, Sum P(2) = 3.9e-14
Identities = 43/192 (22%), Positives = 83/192 (43%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 182 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 239
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 240 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQ 298
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 299 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 358
Query: 333 EAARK-KADNTI 343
+ R K+ TI
Sbjct: 359 DLLRSGKSIRTI 370
>PDB|1DDA|1DDA-A alcohol dehydrogenase
Length = 374
Score = 159 (61.0 bits), Expect = 9.0e-14, Sum P(2) = 9.0e-14
Identities = 36/105 (34%), Positives = 57/105 (54%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E+ + PK EV ++M GIC SD EH + + P+++G
Sbjct: 11 AAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSD----EHVVSGNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYC 111
Score = 73 (30.8 bits), Expect = 9.0e-14, Sum P(2) = 9.0e-14
Identities = 42/192 (21%), Positives = 83/192 (43%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL V+ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
++P ++ + I E ++ + + + G + + GT ++VG+ SQ
Sbjct: 241 INP-QDYKKPIQEVLKEMTDGGVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ P + + + ++ L+T+ E+ + F
Sbjct: 300 NLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNVLPFEKINEGF 359
Query: 333 EAARK-KADNTI 343
+ R K+ T+
Sbjct: 360 DLLRSGKSIRTV 371
>PDB|1HT0|1HT0-A class i alcohol dehydrogenase 3, gamma subunitfragment: gamma
subunit; (alcohol dehydrogenase (class i), gamma polypeptide)aldehyde
reductase; alcohol dehydrogenase 3 (class i), gamma polypeptide;
alcohol dehydrogenase gamma chain; Mutant
Length = 374
Score = 159 (61.0 bits), Expect = 9.0e-14, Sum P(2) = 9.0e-14
Identities = 36/105 (34%), Positives = 57/105 (54%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E+ + PK EV ++M GIC SD EH + + P+++G
Sbjct: 11 AAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSD----EHVVSGNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYC 111
Score = 73 (30.8 bits), Expect = 9.0e-14, Sum P(2) = 9.0e-14
Identities = 42/192 (21%), Positives = 83/192 (43%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL V+ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
++P ++ + I E ++ + + + G + + GT ++VG+ SQ
Sbjct: 241 INP-QDYKKPIQEVLKEMTDGGVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ P + + + ++ L+T+ E+ + F
Sbjct: 300 NLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNVLPFEKINEGF 359
Query: 333 EAARK-KADNTI 343
+ R K+ T+
Sbjct: 360 DLLRSGKSIRTV 371
>PDB|1DEH|1DEH-A human beta1 alcohol dehydrogenase(beta1 adh)
Length = 374
Score = 153 (58.9 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 35/105 (33%), Positives = 56/105 (53%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E + PK EV ++M VGIC +D H + + P+++G
Sbjct: 11 AAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVS----GNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYC 111
Score = 76 (31.8 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 38/177 (21%), Positives = 77/177 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +V+ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSI 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P++ R + F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFD 360
>PDB|1HDX|1HDX-A Alcohol dehydrogenase (beta-1 isoenzyme, human) complexed with
nad(h) and cyclohexanol
Length = 374
Score = 153 (58.9 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 35/105 (33%), Positives = 56/105 (53%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E + PK EV ++M VGIC +D H + + P+++G
Sbjct: 11 AAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVS----GNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYC 111
Score = 76 (31.8 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 38/177 (21%), Positives = 77/177 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +V+ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSI 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P++ R + F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFD 360
>PDB|1HDY|1HDY-A Alcohol dehydrogenase (beta-2 isoenzyme, human) complexed with
nad+ and 4-iodopyrazole
Length = 374
Score = 153 (58.9 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 35/105 (33%), Positives = 56/105 (53%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E + PK EV ++M VGIC +D H + + P+++G
Sbjct: 11 AAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICHTDDHVVS----GNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYC 111
Score = 76 (31.8 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 38/177 (21%), Positives = 77/177 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +V+ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSI 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P++ R + F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFD 360
>PDB|1HSZ|1HSZ-A class i alcohol dehydrogenase 1, beta subunitfragment: beta
subunit; (adh beta-1-subunit)alcohol dehydrogenase 2 (class i), beta
polypeptide;
Length = 374
Score = 153 (58.9 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 35/105 (33%), Positives = 56/105 (53%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E + PK EV ++M VGIC +D H + + P+++G
Sbjct: 11 AAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVS----GNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYC 111
Score = 76 (31.8 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 38/177 (21%), Positives = 77/177 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +V+ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSI 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P++ R + F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFD 360
>PDB|1HTB|1HTB-A beta3 alcohol dehydrogenase(beta3 adh)
Length = 374
Score = 153 (58.9 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 35/105 (33%), Positives = 56/105 (53%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E + PK EV ++M VGIC +D H + + P+++G
Sbjct: 11 AAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVS----GNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYC 111
Score = 76 (31.8 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 38/177 (21%), Positives = 77/177 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +V+ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSI 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P++ R + F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFD 360
>PDB|3HUD|3HUD-A Alcohol dehydrogenase (beta-1 isoenzyme)
Length = 374
Score = 153 (58.9 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 35/105 (33%), Positives = 56/105 (53%)
Query: 7 SAVLYK-QNDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL++ + +E + PK EV ++M VGIC +D H + + P+++G
Sbjct: 11 AAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVS----GNLVTPLPVILG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLC 110
HEA+G V VG+ V +K GD+V C +C+ CK + N C
Sbjct: 67 HEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYC 111
Score = 76 (31.8 bits), Expect = 2.3e-13, Sum P(2) = 2.3e-13
Identities = 38/177 (21%), Positives = 77/177 (43%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL +V+ KA GA ++ + + AK GA T ++P
Sbjct: 187 AKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGA--TECINP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQMVTV 279
++ + I E ++ + + + G + + GT ++VG+ SQ +++
Sbjct: 244 QDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSI 303
Query: 280 -PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAFE 333
P++ R + F+ P + + + ++ L+TH E+ + F+
Sbjct: 304 NPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFD 360
>PDB|1AXE|1AXE-A alcohol dehydrogenaseMutantbiological_unit: dimer;
Length = 374
Score = 155 (59.6 bits), Expect = 5.4e-13, Sum P(2) = 5.4e-13
Identities = 45/154 (29%), Positives = 78/154 (50%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCK--EGKYNLCPDLTFCATPPDD 122
HEA+G V +G+ V ++ GD+V + P C +C+ CK EG + L DL+ D
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKV-IPLWTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQD 125
Query: 123 GNLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
G +R+ H L + + + +++ +SV
Sbjct: 126 GT-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 5.4e-13, Sum P(2) = 5.4e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1ADB|1ADB-A Alcohol dehydrogenase (adh) complexed with
5-beta-d-ribofuranosylnicotinamide adenine dinucleotide (cnad)
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1ADC|1ADC-A Alcohol dehydrogenase (adh) complexed with
5-beta-d-ribofuranosylpicolinamide adenine dinucleotide (cpad)
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1ADF|1ADF Alcohol dehydrogenase complexed with inhibitor: beta-methylene
thiazole-4-carboxamide adenine dinucleotide (beta-tad)
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1ADG|1ADG Alcohol dehydrogenase complexed with inhibitor: beta-methylene
selenazole-4-carboxamide adenine dinucleotide (beta-sad)
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1BTO|1BTO-A liver alcohol dehydrogenase(adh)biological_unit: active as
dimer
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1HLD|1HLD-A Alcohol dehydrogenase (ee isozyme) complexed with nicotinamide
adenine dinucleotide (nad), 2,3,4,5,6-penta-fluorobenzyl alcohol,
p-bromobenzyl alcohol and zinc
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1LDE|1LDE-A liver alcohol dehydrogenase(adh)biological_unit: dimer
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1LDY|1LDY-A alcohol dehydrogenase(adh)biological_unit: dimer of identical
or nonidentical chains
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|2OHX|2OHX-A Alcohol dehydrogenase (holo form) complex with nadh and dmso
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|2OXI|2OXI-A Alcohol dehydrogenase (holo, liver) complexed with nadh and
dmso
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|3BTO|3BTO-A liver alcohol dehydrogenase(adh)biological_unit: active as
dimer
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|5ADH|5ADH Apo-liver alcohol dehydrogenase complex with adp-ribose
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|6ADH|6ADH-A Holo-liver alcohol dehydrogenase complex with nad and dmso
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|8ADH|8ADH Apo-liver alcohol dehydrogenase
Length = 374
Score = 154 (59.3 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 70 (29.7 bits), Expect = 7.3e-13, Sum P(2) = 7.3e-13
Identities = 40/184 (21%), Positives = 79/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1A71|1A71-A liver alcohol dehydrogenaseMutantbiological_unit: dimer
Length = 374
Score = 155 (59.6 bits), Expect = 1.4e-12, Sum P(2) = 1.4e-12
Identities = 45/154 (29%), Positives = 78/154 (50%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCK--EGKYNLCPDLTFCATPPDD 122
HEA+G V +G+ V ++ GD+V + P C +C+ CK EG + L DL+ D
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKV-IPLWTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQD 125
Query: 123 GNLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
G +R+ H L + + + +++ +SV
Sbjct: 126 GT-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 66 (28.3 bits), Expect = 1.4e-12, Sum P(2) = 1.4e-12
Identities = 40/184 (21%), Positives = 78/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGAGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1A72|1A72 horse liver alcohol dehydrogenaseMutantbiological_unit: dimer
Length = 374
Score = 155 (59.6 bits), Expect = 1.4e-12, Sum P(2) = 1.4e-12
Identities = 45/154 (29%), Positives = 78/154 (50%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVP-CRRCQFCK--EGKYNLCPDLTFCATPPDD 122
HEA+G V +G+ V ++ GD+V + P C +C+ CK EG + L DL+ D
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKV-IPLWTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQD 125
Query: 123 GNLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
G +R+ H L + + + +++ +SV
Sbjct: 126 GT-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 66 (28.3 bits), Expect = 1.4e-12, Sum P(2) = 1.4e-12
Identities = 40/184 (21%), Positives = 78/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGAGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1AXG|1AXG-A alcohol dehydrogenaseMutantbiological_unit: dimer
Length = 374
Score = 154 (59.3 bits), Expect = 1.9e-12, Sum P(2) = 1.9e-12
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 66 (28.3 bits), Expect = 1.9e-12, Sum P(2) = 1.9e-12
Identities = 40/184 (21%), Positives = 78/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGAGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++VG+ SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1QLH|1QLH-A alcohol dehydrogenase(adh, alcohol dehydrogenase e
chain)Mutant
Length = 374
Score = 154 (59.3 bits), Expect = 3.0e-12, Sum P(2) = 3.0e-12
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 64 (27.6 bits), Expect = 3.0e-12, Sum P(2) = 3.0e-12
Identities = 39/184 (21%), Positives = 78/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++V + SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVAVTPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1QLJ|1QLJ-A alcohol dehydrogenase(adh)Mutant
Length = 374
Score = 154 (59.3 bits), Expect = 3.0e-12, Sum P(2) = 3.0e-12
Identities = 44/153 (28%), Positives = 76/153 (49%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + PK EV ++M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD+V C +C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGKPIHHFLGTS-TFSQYTVVDEISV 157
Score = 64 (27.6 bits), Expect = 3.0e-12, Sum P(2) = 3.0e-12
Identities = 39/184 (21%), Positives = 78/184 (42%)
Query: 160 ACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLV 218
A + A V G+T V G G +GL ++ KA GA ++ + + AK GA T
Sbjct: 183 AVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGA--TEC 240
Query: 219 VDPAKEEESSIIERIRSAIGDLPNVTIDCSGNEKCITIGINITRTG-GTLMLVGM--GSQ 275
V+P ++ + I E + + + + G + ++ + G ++V + SQ
Sbjct: 241 VNP-QDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVAVTPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E+ + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|7ADH|7ADH Isonicotinimidylated liver alcohol dehydrogenase
Length = 374
Score = 141 (54.7 bits), Expect = 2.6e-10, Sum P(2) = 2.6e-10
Identities = 43/153 (28%), Positives = 72/153 (47%)
Query: 7 SAVLYKQND-LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIG 65
+AVL+++ +E+ + P EV + M GIC SD H G + + P++ G
Sbjct: 11 AAVLWEEXXPFSIEEVEVAPPXAHEVRIXMVATGICRSDDHVVS-GTL---VTPLPVIAG 66
Query: 66 HEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRRCQFCK--EGKYNLCPDLTFCATPPDDG 123
HEA+G V +G+ V ++ GD V C C+ CK EG + L DL+ DG
Sbjct: 67 HEAAGIVESIGEGVTTVRPGDXVIPLFTPQCGXCRVCKHPEGNFCLXNDLSMPRGTMQDG 126
Query: 124 NLARYYVHAADFCHKLPDNVSLEEGALLEPLSV 156
+R+ H L + + + +++ +SV
Sbjct: 127 T-SRFTCRGXPIHHFLGTS-TFSQYTVVDEISV 157
Score = 60 (26.2 bits), Expect = 2.6e-10, Sum P(2) = 2.6e-10
Identities = 40/184 (21%), Positives = 75/184 (40%)
Query: 164 AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAF-VVCTARSPRRLEVAKNCGADVTLVVDPA 222
A V G+T V G G +GL ++ A GA ++ + AK GA T V+P
Sbjct: 187 AXVTQGSTCAVFGLGGVGLSVIMGCXAAGAARIIGVDINXDXFAXAKEVGA--TECVNP- 243
Query: 223 KEEESSIIERIRSAIGDLPNVTIDCS----GNEKCITIGINITRTG-GTLMLVGM--GSQ 275
+ I+ + ++ N +D S G + ++ + G ++VG+ SQ
Sbjct: 244 ----QDYXKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQ 299
Query: 276 MVTV-PLVNACAREID--IKSVFRYCNDYPIALEMVASGRCNVKQLVTHSFKLEQTVDAF 332
+++ P++ R I F+ + P + + + + L+TH E + F
Sbjct: 300 NLSMNPMLLLSGRTWKGAIFGGFKSXDSVPXLVADFMAKKFALDPLITHVLPFEXINEGF 359
Query: 333 EAAR 336
+ R
Sbjct: 360 DLLR 363
>PDB|1QOR|1QOR-A Quinone oxidoreductase complexed with nadph
Length = 326
Score = 95 (38.5 bits), Expect = 2.2e-06, Sum P(2) = 2.2e-06
Identities = 25/64 (39%), Positives = 35/64 (54%)
Query: 25 EPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKVGKNVKHLKK 84
+P E+E+ ++ +GI D Y G + P +G EA+G V KVG VKH+K
Sbjct: 24 DPAENEIQVENKAIGINFIDT-YIRSGLYPPPSL--PSGLGTEAAGIVSKVGSGVKHIKA 80
Query: 85 GDRV 88
GDRV
Sbjct: 81 GDRV 84
Score = 71 (30.1 bits), Expect = 2.2e-06, Sum P(2) = 2.2e-06
Identities = 38/150 (25%), Positives = 68/150 (45%)
Query: 133 ADFCHKLPDNVSLEEGA--LLEPLSVGVHACRRAGVQLGTTVLV-IGAGPIGLVSVLAAK 189
AD LP +S E+ A L+ L+V + ++ L AG +GL++ AK
Sbjct: 102 ADKAAILPAAISFEQAAASFLKGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQWAK 161
Query: 190 AYGAFVVCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLP-NVTIDCS 248
A GA ++ T + ++ + A GA V++ +EE+ ++ER++ G V D
Sbjct: 162 ALGAKLIGTVGTAQKAQSALKAGA--WQVIN-YREED--LVERLKEITGGKKVRVVYDSV 216
Query: 249 GNEKCITIGINITRTGGTLMLVGMGSQMVT 278
G + ++ + G ++ G S VT
Sbjct: 217 GRDTWER-SLDCLQRRGLMVSFGNSSGAVT 245
WARNING: HSPs involving 32 database sequences were not reported due to the
limiting value of parameter B = 50.
Parameters:
E=10
B=50
V=100
matrix=blosum62
sump
cpus=4
ctxfactor=1.00
Query ----- As Used ----- ----- Computed ----
Frame MatID Matrix name Lambda K H Lambda K H
+0 0 blosum62 0.321 0.138 0.411 same same same
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
Query
Frame MatID Length Eff.Length E S W T X E2 S2
+0 0 352 352 10. 65 3 11 22 0.19 34
34 0.22 37
Statistics:
Database: /ebi/services/idata/blastdb/pdb
Title: pdb
Posted: 9:27:12 AM GMT Feb 28, 2001
Created: 9:27:12 AM GMT Feb 28, 2001
Format: XDF-1
# of letters in database: 4,016,585
# of sequences in database: 18,733
# of database sequences satisfying E: 82
No. of states in DFA: 555 (118 KB)
Total size of DFA: 275 KB (1134 KB)
Time to generate neighborhood: 0.01u 0.01s 0.02t Elapsed: 00:00:00
No. of threads or processors used: 4
Search cpu time: 3.57u 0.08s 3.65t Elapsed: 00:00:01
Total cpu time: 3.70u 0.13s 3.83t Elapsed: 00:00:02
Start: Fri Mar 30 15:28:28 2001 End: Fri Mar 30 15:28:30 2001
WARNINGS ISSUED: 1