Alfonso Valencia (PDG - Centro Nacional de Biotecnología, Madrid).
Protein structure prediction
Fold Recognition / Threading / Inverse Folding
Threading query
Elements of a fold recognition algorithm
Dynamic programming with environmental strings
What are environments?
How do you thread a new sequence?
Contact potential threading
Knowledge based threading potential I
Knowledge based threading potential II
Using knowledge based threading potential I
Why threading
Why not threading
Slide 15
Preferences used by TOPITS (RostÕ 96)
Slide 17
Threadlize
CASP3 T0081 (methylglyoxal synthase) threaded on 2liv
Slide 20
Assessing the assessment.
Casp4: our predicitons
Slide 23
CAFASP Servers for Automatic Structure Predictions
CAFASP main conclusions
CAFASP results MaxSub Evaluation on 26 Fold Recognition Targets
CAFASP results MaxSub Evaluation on 21 Hard Fold Recognition Targets
CAFASP results MaxSub Top 5 Evaluation on 21 Hard Fold Recognition Targets
Threading practical applications.
Slide 30
